2012-05-10

5422

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Kred-130

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125 000. 130 000. 135 000. 140 000. 145 000.

Räkningar. 66.

In a 2.0 mL Eppendorf tube, KRED (2 mg), 3 (27 mM), DMSO (55 μL) and i‐PrOH (165 μL) were added to 900 μL of 125 mM KH 2 PO 4 buffer (1.25 mM MgSO 4, 1 mM NADP +) pH 7.0 or 900 μL of 250 mM KH 2 PO 4 buffer (2 mM MgSO 4, 1.1 mM NADP +, 80 mM d ‐glucose, 10 U/mL glucose dehydrogenase) pH 7.0 in the case of KRED‐101, KRED‐119, KRED‐130, KRED‐NADH‐101 and KRED‐NADH‐110.

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Kred-130

In 2016, Clayden and co-workers developed a biocatalytic reduction for the atropo-enantioselective synthesis of axially chiral heterobiaryl N-oxides via dynamic kinetic resolution . 44 Particularly, a ketoreductase (KRED 130) was used for the reduction of a configurationally unstable heterobiaryl ketone under mild conditions, while glucose is oxidized to gluconic acid.

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Kred-130

19 pol. brak 3 1818 [Protokół posiedzeń Komisji Nadzoru Budowl Korony] poszyt, s. 11 pol. brak 4 1820 funkcionalnosti – razvrstavanje imovine prema funkciji ili namjeni imovine u poslovnim procesima likvidnosti – promatra brzinu transformacije nenovčanih oblika imovine u novac opadajuća likvidnost – opada stupanj likvidnosti imovine, unose se najprije pozicije najlikvidnija imovina, nakon toga manje likvidna imovina, a zadnja pozicija najmanje likvidna imovina rastuća likvidnost The use of enzymes was restricted to selective modification of racemic mixtures in kinetic resolution (KR) procedures, resulting in a maximum 50% yield of the enantiopure product 14-20 or reduction of prochiral compounds.

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44 Particularly, a ketoreductase (KRED 130) was used for the reduction of a configurationally unstable heterobiaryl ketone under mild conditions, while glucose is oxidized to gluconic acid. pH and substrate (2) concentrations for KRED 130 (Codexis) and ketoreducatase from W02011/000693.